Cosette and Cleveland only lived together for a short time, but it was enough to change Cleveland’s life.

Dogs from shelters in the south are getting second chances and new homes in Minnesota.

Midge was down on her luck in a Las Vegas shelter, but today she’s in the perfect home in Salt Lake City with three new best friends.

After years in the shelter system, Parker the dog got the chance to go into foster care, won the hearts of his foster family and found a forever home.

Ludo’s friends come together to celebrate the gentle giant who loves life.

Xenia, a kitten with feline leukemia, arrived at the kitten nursery with life-threatening injuries, but now she’s happy in a home of her own.

Volunteer Connie Murphy has put in more than 1,000 hours helping to save newborn kittens in Los Angeles.

Training initiatives help shelter cats stay happy — and find their happily-ever-afters.

A very special therapy dog helps one child at a time.

After receiving help from Best Friends in Utah, Posh Spice not only felt better, but she also caught the eye of an adopter in Canada.

Sadie and William Pear both lost the use of their hind legs, but physical therapy helped them get back on the fast track.

The adoption of Pancake, Ella and Snowflake is proof that, sometimes, good things come in threes.

Thelma and Louise ended up at a Los Angeles shelter with terrible flea dermatitis, but these senior dogs never stopped being best friends, even in their new homes.

Watch Joey go from scared to smiling — all thanks to his foster mom’s love and care.

Senior cat Sophie was in a lot of pain from a botched declaw surgery until Best Friends found her the care (and the home) she needed to feel better again.

Foster volunteers in Houston are truly giving dogs at the Harris County Animal Shelter a second chance at life

Feline distemper left this kitten with cerebellar hypoplasia, but wobbly legs and a bobbing head can’t keep Jelly down.

Lego couldn’t always hide his fear, but his new family saw through it and gave him the chance he deserved.

Dogtown team lead Tierney Sain shares what it’s like to work with hundreds of dogs who through the years have called Best Friends their home between homes.

Best Friends helps a cat named Fawkes rise from his days of spitting and hissing at everyone in the shelter, to a wonderful life with an adopter who needed a little happiness of her own.

Volunteers tell us what they love the most about their fabulous, furry and four-legged sleepover guests.

Fiona likes people better than other cats, so at the Sanctuary she gets her own perfect spot to stay.

How emergency surgery for cat with urinary blockage saved Simon’s life, and then he got a new home.

Rescuing a bobcat rescue is all in a day’s work for tireless volunteer.

Surgery saved Shorty the dachshund’s life, love brought him home, and forgiveness helped him make a new friend.

Together, Best Friends and L.A. city shelters are helping puppies with parvovirus beat the odds.

Puppy has a birth defect that made it impossible for him to nurse, but today he’s thriving and utterly adorable.

It took a long time for Swing to join his family, but his happy ending was worth the wait.

For Charger, a paddle-boarding, couch-loving dog who has been blind since birth, the world is his oyster.

Abraham and Alfonso probably wouldn’t have survived on the streets, but at the Sanctuary these young cats with feline leukemia are celebrating milestones.

Hobbes waited longer than most cats to be adopted at the Best Friends Pet Adoption Center in Atlanta, but now he’s living large in his new home

From pigs to parrots, puppies and a pony, here are a few joyful snapshots from saving animals throughout the holidays.

After being rescued from a puppy mill in 2009, Piper the pug lived a long, charmed life with her adopter.

In the shelter, this puppy used to curl up in her food bowl for comfort, but now she’s spoiled and on her way to a new home.

Dogs, cats and their incredible stories of overcoming the odds to find safety and love

Heismann is selective about his friends, but at the Sanctuary he has more friends than ever, thanks to a bit of structure and a lot of understanding.

In animal welfare, tech innovation is helping to save lives.

Some are funny, some might make you cry happy tears, but all these moments with animals from Best Friends will make your day a little bit better.

After getting help with her allergies, this former shelter cat has finally landed in just the right lap.

Audrey couldn't even stand up when she came to Best Friends, but now she has a new lease on life.

Pet fostering for your local rescue or shelter makes a huge difference in the life of a homeless dog or cat, and it helps open more space for another pet in need.

Advanced heartworm disease almost took Arrow’s life, but now he’s living his best life in a home.

When an overweight cat named Tortie came to the Best Friends Pet Adoption and Spay/Neuter Center in L.A., the staff helped her slim down and get a perfect new home.

Fostering pets is not only fun, but it’s critical for getting to no-kill.

Volunteer Janice MacMillan has a soft spot for fearful dogs, so when she met Donner she knew she wanted to help her.

Hurricane survivor DoSiDo has anxiety and laryngeal paralysis, but she’s now loving life in her new home.

How Rosie, a dog at a busy Atlanta shelter, received the care she needed at Best Friends to heal from mange and find a home

Meet Michael Moran, a Los Angeles Police Department reserve officer/detective and foster dad who steps up in a big way to help newborn kittens, including kittens with ringworm.

Couple starts scholarship fund and donates handmade blankets and leashes to Sanctuary pets to honor the memory of their daughter, Isabel.